Staining Methods. Histologic and Histochemical

fond of statements such as "buffer action is ultimately dependent on a spacetime frame of reference." The main fault of this book, however, is that so much of it is outdated. It seems surprising that a text concerned with rational drug design should lack a discussion of protein structure and does not list deoxyribonucleic and ribonucleic acids in its index. Sulfonamide action is discussed without any mention of folic acid. The structures of coenzyme A and muscarine shown were proven to be incorrect several years ago. A discussion of acetylcholinesterase omits any mention either of "nerve gases," which act by profound inhibition of this enzyme, or of the compounds designed to reverse this inhibition. Analgesics are discussed in terms of "mixed sympathominetic and parasympathomimetic pharmacophoric moieties"; there is no mention of Beckett's concept of "analgesic receptor sites." Factual errors, misprints, and incorrect structural formulae are numerous. Heterocyclical structures are often printed in a way which makes it difficult to see what compound is being depicted. In view of the shortcomings and the high cost of this text it can be recommended neither to the physicians nor to the chemists for whom it was intended.